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General Pharmacometrics Guide

Recent articles in our ecosystem

An automated sampling importance resampling procedure for estimating parameter uncertainty.
Dr. Anne-Gaëlle Dosne | 20-Feb-2019

I found this article to be interesting because it provides an assumption-light and efficient procedure to obtain parameter uncertainty in nonlinear mixed-effects models

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Scientific white paper on concentration-QTc modeling
Christine Garnett, PharmD | 20-Feb-2019

I like this article because it provides an excellent guidance on how to approach the modeling of QT prolongation in well-designed early phase I studies as a potential alternative approach to a thorough QT study to reliably exclude clinically relevant QTc effects.

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